Understanding Bone Cancer in Dogs

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You don't want to think about your dog getting sick, but staying informed can help you navigate even the most difficult situations — including cancer. Osteosarcoma is the most common bone cancer in dogs. The Morris Animal Foundation reports that more than 10,000 cases occur each year, accounting for more than 85% of all canine bone cancer diagnoses. Knowing the signs of bone cancer in dogs is an important part of getting your pal help sooner.

What Is Bone Cancer?

Osteosarcoma is a cancer of osteoblasts, which are bone stem cells. A malignant cancer, osteosarcoma spreads to other parts of the body, including the lungs, lymph nodes, skin, liver, kidney and other bones. While osteosarcoma can affect any bone in the body, it most commonly attacks the long bones of the legs, usually near the ends of the bones, and often appears around the wrists and knees. Osteosarcoma can occur in dogs of any age or breed, but older dogs and large breeds are more affected. Golden retrievers, Rottweilers, Irish wolfhounds, Great Danes, boxers, Irish setters, greyhounds, Doberman pinschers and German shepherds appear to be at increased risk for this disease.

The cause of osteosarcoma is likely genetic. Other contributing factors can include chronic inflammation associated with metal implants and prior radiation therapy. Based on a study in Frontiers in Veterinary Science, early spaying or neutering in certain breeds is another possible risk factor. While osteosarcoma is the most common type of bone cancer in dogs, other bone cancers include fibrosarcoma and chondrosarcoma. Cancer can also spread from other organs, including the prostate and mammary glands, to your dog's bones.

An adult dog at a veterinarian


The most common, and often first noticed, signs of bone cancer in dogs are limping and pain in the affected leg. The degree of limping and pain can range from mild lameness to refusing to put any weight on the leg. There may also be a firm, painful swelling on the bone that has cancer. Because cancer weakens the bone, some dogs develop a pathological fracture of the affected bone, which causes sudden severe limping and pain.


Your veterinarian is key in determining if your dog has any type of bone disease. Because the signs of bone cancer in dogs can mimic other conditions, like fungal or bacterial infections of the bone, they'll need to run some tests to identify what's causing your dog's pain. Preliminary testing typically includes laboratory tests on blood and urine and radiographs (X-rays) of your dog's bone. Your vet will usually also take radiographs of your dog's chest to check for any sign of metastatic cancer in the lungs.

If your vet suspects bone cancer, they'll likely recommend additional testing that can include nuclear bone scans, a bone biopsy or a bone aspiration. These procedures are done under sedation or anesthesia. A bone aspiration is a relatively noninvasive procedure; your vet will insert a needle into the bone to withdraw cells to be analysed in a laboratory. A bone biopsy is more invasive, but it's the best way to diagnose bone cancer as it's highly accurate. With either procedure, your dog will be asleep and will receive pain medication so they don't feel any discomfort.


Unfortunately, the long-term prognosis for osteosarcoma is poor. According to Blackwell's Five-Minute Veterinary Consult,1 15% of dogs diagnosed with osteosarcoma do manage to live for years after aggressive cancer treatment. In most cases, however, treatment is aimed at relieving pain associated with bone cancer, and remission is unlikely. With surgery alone, survival time is around four months. The good news is that a vaccine currently in testing may be able to fight cancer in dogs using their tumor cells, according to Veterinary Practice News.

For dogs diagnosed with chondrosarcoma and fibrosarcoma who receive aggressive cancer treatment, Blackwell's Consult estimates the median survival time to be greater than three years, and many dogs do well during and after treatment. If these cancers spread, however, the prognosis is poor.

Amputating the affected leg is the treatment of choice for bone cancer, whether you're hoping to stop the cancer or remove the source of pain. Limb-sparing surgery is available at a few referral surgery centers for select pups. If you're interested in this surgery, ask your vet for more information. In addition to surgery, chemotherapy and radiation therapy are both available and have varying levels of success depending on the bone cancer diagnosis. For treatment beyond surgery, work with a veterinary cancer doctor, or oncologist, to get the best cancer care for your dog.

In all dogs, pain management is a cornerstone of therapy and is always prescribed to maintain the best quality of life possible.

Can You Prevent Bone Cancer in Dogs?

While bone cancer in dogs is often a genetic issue, you can take steps to minimise your dog's risk of developing cancer, including bone cancer. Strategies include:

  • If you choose to adopt a puppy from a breeder, ensure the breeder is reputable, certifies their breeding animals to be free of genetic disease and provides you with a health guarantee for your puppy.
  • Keep your dog at a healthy weight and feed them a complete and balanced meal plan that's rich in antioxidants, including EPA and DHA. Obesity is an inflammatory condition that predisposes dogs to all types of cancers.
  • Talk to your vet about the right time to spay or neuter your dog.
  • Bring your dog to the vet once a year for a full physical examination.
  • Avoid exposure to environmental toxins, such as secondhand smoke and toxic chemicals.

You want the best for your dog. And while you can't control whether they develop a certain illness, you can provide them with proper nutrition, care and love and stay informed about the best ways to monitor their health to help ensure a happy life together.

1Jr., F. S. W. K., Tilley, L. P. (2015). Blackwell's Five-Minute Veterinary Consult: Canine and Feline (6th ed.). Wiley-Blackwell.

Contributor Bio

Dr. Sarah Wooten

Dr. Sarah Wooten

A 2002 graduate of UC Davis School of Veterinary Medicine and certified veterinary journalist, Dr. Sarah Wooten has 16 years experience in small animal veterinary practice, is a well known international speaker and writer in the veterinary and animal health care spaces, and is passionate about helping pet parents learn how to care better for their fur friends.